We are seeking a Senior Scientist or Principal Scientist to join our Biotherapeutic team. This role focuses on in vitro characterization and pre-clinical drug development, contributing to the development of therapeutic antibodies. The ideal candidate will have a Ph.D. in a relevant scientific field with industry experience, with expertise in cell biology, immunology and molecular biology.

Key Responsibilities:

In Vitro Characterization:

• Design, develop, and optimize in vitro assays to assess the biological activity, potency, and mechanism of action of therapeutic molecules.
• Conduct immunological assays including binding affinity, epitope mapping, and functional tests (ADCC, CDC, neutralization, ADC) to evaluate candidate molecules.

Pre-Clinical Drug Development:

• Develop and support pre-clinical models, including in vivo studies, to drive IND-enabling experiments and regulatory submissions.
• Collaborate with cross-functional teams to assess pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of lead candidates.
• Partner with Contract Research Organizations and collaborators to oversee in vitro/in vivo testing and ensure comprehensive antibody characterization.

Cross-Functional Collaboration:

• Work closely with discovery and bioanalytical teams internally and externally to align on project timelines and objectives.
• Contribute to data analysis, interpretation, and communication in cross-functional meetings and external scientific forums.
• Support collaborations with external academic and industry partners for advanced therapeutic antibody research.

Documentation & Reporting:

• Prepare detailed technical reports, standard operating procedures (SOPs), and regulatory documentation to support IND submissions.
• Present scientific findings at internal and external meetings, as well as contribute to publications, patents, and federal grants.

Qualifications:

• Ph.D. or equivalent in cell biology, immunology, molecular biology, biochemistry, or a related discipline, with at least 2 years industrial experience in a related field.

Desired Skills:

• Strong background and broad knowledge of cell biology, immune oncology, and pharmacology.
• Proficiency in designing and execution on cellular biological, immunological and biochemical assays such as multi-color flow cytometry (FACS), ELISA, western blotting, IHC, ICC, and cell-based assays.
• Hands-on experience with primary cell culture (T cells/B cells), in vitro, in vivo, ex vivo models, and evaluating immune responses.
• Familiarity with pre-clinical development processes, including PK/PD studies and regulatory guidelines.

Eligibility Requirements:

• Must be legally authorized to work in the U.S.A.

Application Process:
Interested candidates are encouraged to submit their resumes with a cover letter to jobs@abbratech.com , detailing their experience and passion for therapeutic antibody development.